Management strategies of Barrett's esophagus

Barrett's Esophagus: Emerging Knowledge and Management Strategies

The incidence of esophageal adenocarcinoma (EAC) has increased exponentially in the last 3 decades. Barrett's esophagus (BE) is the only known precursor of EAC. Patients with BE have a greater than 40 folds higher risk of EAC compared with the general population. Recent years have witnessed a revolution in the clinical and molecular research related to BE. However, several aspects of this condi...

Management of Barrett's esophagus.

Barrett's esophagus represents replacement of normal distal esophageal squamous epithelium with specialized columnar epithelium containing goblet cells. Typically arising in the setting of chronic gastroesophageal reflux disease, the presence of Barrett's esophagus carries a 50- to 100-fold increased risk of developing esophageal cancer. Risk factors include male sex, smoking history, obesity, ...

CCR New Strategies New Strategies in Barrett's Esophagus: Integrating Clonal Evolutionary Theory with Clinical Management

Barrett’s esophagus is a condition in which the normal stratified squamous epithelium of the distal esophagus is replaced by intestinal metaplasia. For more than three decades, the prevailing clinical paradigm has been that Barrett’s esophagus is a complication of symptomatic reflux disease that predisposes to esophageal adenocarcinoma. However, no clinical strategy for cancer prevention or ear...

Endoscopic management of Barrett's esophagus.

Barrett’s Esophagus: Evaluation and Management

history The patient has no significant past medical history other than being overweight. He drinks 1 glass of wine per day and does not smoke. Family medical history is unremarkable for any malignancies. He does not exercise because he “works all the time” and has gained approximately 22 lb over the last year. The patient describes his heartburn symptom as a substernal “burning” sensation, whic...